Why Are Obese People Predisposed to Severe Disease in Viral Respiratory Infections?
نویسندگان
چکیده
Obesity is one of the most pressing healthcare concerns twenty-first century. prevalence has risen dramatically in recent decades, and 2016, more than 1.9 billion adults were overweight (BMI ≥ 25 kg/m2) 650 million obese 30 kg/m2). About 50% world’s population anticipated to be obese/overweight within next decade. a major risk factor for variety non-communicable diseases, including type 2 diabetes mellitus, cardiovascular disease, non-alcoholic fatty liver malignancies. emerged as substantial hospitalization death from viral respiratory infections such influenza A ongoing pandemic SARS-CoV-2. Several independent studies have indicated that patients are at higher severe disease these diseases. Excess fat, particularly visceral contributes development metabolic disorders, persistent systemic inflammation decreased immunological function. As result, response infectious pathogens weakened, resulting poorer outcomes post-infection. Additionally, poor lung mechanics associated with obesity may increase serious infections. In this review, we address likely mechanism(s) predispose people diseases caused by
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ژورنال
عنوان ژورنال: Obesities
سال: 2023
ISSN: ['2673-4168']
DOI: https://doi.org/10.3390/obesities3010005